[Clinical and Biological Character in Mouse Models for Middle East Respiratory Syndrome Generated by Transduction with Different Doses of DPP4 Molecule].
Identifieur interne : 001508 ( Main/Exploration ); précédent : 001507; suivant : 001509[Clinical and Biological Character in Mouse Models for Middle East Respiratory Syndrome Generated by Transduction with Different Doses of DPP4 Molecule].
Auteurs : Yanfeng Yao ; Jiaming Lan ; Fengdi Li ; Peihua Niu ; Pin Yu ; Lu Shuai ; Linlin Bao ; Wenjie Tan ; Chuan QinSource :
- Bing du xue bao = Chinese journal of virology [ 1000-8721 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (métabolisme), Femelle, Humains, Infections à coronavirus (anatomopathologie), Infections à coronavirus (enzymologie), Infections à coronavirus (génétique), Infections à coronavirus (virologie), Modèles animaux de maladie humaine, Souris, Souris de lignée BALB C.
- MESH :
- anatomopathologie : Infections à coronavirus.
- enzymologie : Infections à coronavirus.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Dipeptidyl peptidase 4, Infections à coronavirus.
- métabolisme : Dipeptidyl peptidase 4.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Infections à coronavirus.
- Animaux, Femelle, Humains, Modèles animaux de maladie humaine, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals, Coronavirus Infections (enzymology), Coronavirus Infections (genetics), Coronavirus Infections (pathology), Coronavirus Infections (virology), Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Disease Models, Animal, Female, Humans, Mice, Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (physiology).
- MESH :
- chemical , genetics : Dipeptidyl Peptidase 4.
- enzymology : Coronavirus Infections.
- genetics : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- chemical , metabolism : Dipeptidyl Peptidase 4.
- pathology : Coronavirus Infections.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections.
- Animals, Disease Models, Animal, Female, Humans, Mice, Mice, Inbred BALB C.
Abstract
In this study, we evaluated the difference ot biological characteristics in the MERS-CoV infected mice model in prior to transduction with different dosage of human DPP4. Firstly, we transduced different dosage of DPP4 (high or low) into mice, and then challenged them with MERS-CoV in order to establish the model. After establishment of mice model, we observed the clinical signs of disease, virus replication, immunopathogenesis and antibody response. The results indicated that the infected mice showed typical pneumonia, virus replication, histological lesions, and neutralizing antibody production. Moreover, the high dosage group was superior to the low dosage group. Fourteen days after infection, the specific antibody to virus structural protein and neutralizing antibody were analyzed, the high dosage group induced higher level antibody. In summary, the MERS-CoV infected mice model were established prior transduction with DPP4, and the level of DPP4 influenced the clinical signs of disease, virus replication and antibody response in this model.
PubMed: 26951002
Affiliations:
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Le document en format XML
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uniqKey="Niu P" first="Peihua" last="Niu">Peihua Niu</name></author><author><name sortKey="Yu, Pin" sort="Yu, Pin" uniqKey="Yu P" first="Pin" last="Yu">Pin Yu</name></author><author><name sortKey="Lu Shuai" sort="Lu Shuai" uniqKey="Lu Shuai" last="Lu Shuai">Lu Shuai</name></author><author><name sortKey="Bao, Linlin" sort="Bao, Linlin" uniqKey="Bao L" first="Linlin" last="Bao">Linlin Bao</name></author><author><name sortKey="Tan, Wenjie" sort="Tan, Wenjie" uniqKey="Tan W" first="Wenjie" last="Tan">Wenjie Tan</name></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name></author></analytic><series><title level="j">Bing du xue bao = Chinese journal of virology</title><idno type="ISSN">1000-8721</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coronavirus Infections 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coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptidyl Peptidase 4</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dipeptidyl peptidase 4</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, 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In summary, the MERS-CoV infected mice model were established prior transduction with DPP4, and the level of DPP4 influenced the clinical signs of disease, virus replication and antibody response in this model.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bao, Linlin" sort="Bao, Linlin" uniqKey="Bao L" first="Linlin" last="Bao">Linlin Bao</name><name sortKey="Lan, Jiaming" sort="Lan, Jiaming" uniqKey="Lan J" first="Jiaming" last="Lan">Jiaming Lan</name><name sortKey="Li, Fengdi" sort="Li, Fengdi" uniqKey="Li F" first="Fengdi" last="Li">Fengdi Li</name><name sortKey="Lu Shuai" sort="Lu Shuai" uniqKey="Lu Shuai" last="Lu Shuai">Lu Shuai</name><name sortKey="Niu, Peihua" sort="Niu, Peihua" uniqKey="Niu P" first="Peihua" last="Niu">Peihua Niu</name><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><name sortKey="Tan, Wenjie" sort="Tan, Wenjie" uniqKey="Tan W" first="Wenjie" last="Tan">Wenjie Tan</name><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><name sortKey="Yu, Pin" sort="Yu, Pin" uniqKey="Yu P" first="Pin" last="Yu">Pin Yu</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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